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Contents

  1. Parkinson disease genetics: too early to predict progression?
  2. Identifying candidate genes for Parkinson’s disease by integrative genomics method
  3. 17 New Genetic Variants Linked To Parkinson's Disease | Parkinson's Disease
  4. More from Genetics Home Reference

Parkinson disease genetics: too early to predict progression?

They can, but it's rare and only affects a small number of families. About 1 in people with Parkinson's get it this way.

Your environment is a hard one to pin down. Partly, that's because it covers a lot of ground. It's everything that's not your genes, which could mean where you live, what you eat, chemicals you've come into contact with, and more.


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Not only that, but it could take years for the effects from something in your environment to show up. So far, doctors have a lot of clues but no smoking gun. So you could have people who live or work in an area around chemicals tied to Parkinson's, but many of them don't get it. These can come into play based on where you live, what you do for work, or if you served in the military. Sometimes, these chemicals seep into well water, so that's one more way they can affect you.

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Identifying candidate genes for Parkinson’s disease by integrative genomics method

Since it mostly affects people 60 and older, your risk goes up as the years go by. Family history. If your parent, brother, or sister has it, you're a little more likely to get it. Some types of work, like farming or factory jobs, can cause you to have contact with chemicals linked to Parkinson's. Serious head injury.


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  • The complicated world of genetic testing for Parkinson’s disease?
  • If you hit your head hard enough to lose consciousness or forget things as a result of it, you may be more likely to get Parkinson's later in life. Where you live. People in rural areas seem to get it more often, which may be tied to chemicals used in farming. As scientists try to learn what's at the root of Parkinson's, they're looking far and wide to pick up clues where they can.

    They've found that people with Parkinson's tend to have something called Lewy bodies in their brain.


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    These are unusual clumps of a protein called alpha-synuclein. The protein itself is normal, but the clumps are not.

    Khan Academy - Genetics and Parkinson's Disease

    And they're found in parts of the brain that affect sleep and sense of smell, which could explain some symptoms of Parkinson's not related to movement. Your gut may also have a part in it, as some of its cells make dopamine, too.

    17 New Genetic Variants Linked To Parkinson's Disease | Parkinson's Disease

    Some doctors think that this might be where the earliest signs of Parkinson's show up, but that idea needs more research. But it's rare for the disease to be inherited this way. Some researchers also feel environmental factors may increase a person's risk of developing Parkinson's disease. Parkinson's disease is the most common type of parkinsonism, but there are also some rarer types where a specific cause can be identified. You can read more about parkinsonism on the Parkinson's UK website. Page last reviewed: 30 April Next review due: 30 April Nerve cells in this part of the brain are responsible for producing a chemical called dopamine.

    More from Genetics Home Reference

    If these nerve cells die or become damaged, the amount of dopamine in the brain is reduced. What causes the loss of nerve cells? Environmental factors Some researchers also feel environmental factors may increase a person's risk of developing Parkinson's disease.